INTERNATIONAL ASSOCIATION OF BIOMEDICAL SCIENCES

  “ IABS Forum-2023 ” December 2023
ABSTRACT

Requirement for an Effective Treatment of Neurodegenerative Diseases

William Rodman Shankle

Shankle Clinic for Alzheimer’s Disease and Related Disorders; Medical Care Corporation

  ABSTRACT

 For degenerative diseases, a major causal hypothesis is chronic cell stress, which damages cell proteins. To maintain cellular homeostasis, damaged proteins must be replaced via nuclear protein synthesis, ER folding, and Golgi transport. If protein damage exceeds the cell’s replacement capacity, protein misfolding occurs, which, if unchecked, forms cytotoxic aggregates of misfolded polymorphic structures (CAMPS) that attach to membranes, disrupt their function, and degrade homeostasis.
 Compensatory processes for preserving cell homeostasis include degradation of misfolded proteins by size-dependent processes of autophagy, proteasome digestion, and apoptosis, plus generation of multiple clones of IgG antibodies to bind and remove accumulating CAMPS pathologies. Failure of these processes   to compensate for chronic cell stress leads to loss of homeostasis and degenerative disease.
 Monoclonal IgG antibodies against specific CAMPs pathology, have been used to treat Alzheimer’s disease. This treatment approach has failed or been marginally effective. Over the past 20 years, treating thousands of patients with neurodegenerative diseases, I have found that they can be substantially delayed, stopped, or partially reversed, in direct proportion to how effectively CAMPS pathology accumulation is treated. To date, the most effective treatment has been intranasal delivery of human polyclonal IgG antibodies, derived from thousands of donors, which penetrates the nose-brain barrier ~30 times greater than intravenous IgG penetrates the blood brain barrier. My findings are consistent with Charlie Glabe’s findings that any given AD patient has many different clones of anti-CAMPS IgG antibodies. These findings suggest that patient-specific characterization and removal of all their CAMPS pathologies will more effectively treat patients with degenerative disease.

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