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International Journal of Biomedical Science
1(1) 67-71
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© 2005 Master Publishing Group
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Original Article
[FullText]
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Changes of noradrenaline in brain homogenate of rats with brain injury secondary to intracerebral hemorrhage: a study of the mechanism |
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Zhi-Qiang Xu, Hua-Dong Zhou, Xiao-Jiang
Jiang,
Jing-Zhou Wang, Man-E Chen |
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Third Department of Neurology, Daping Hospital,
Research Institute of Surgery, Third Military Medical University, Chongqing
400042, China. Telephone: 86-23-68757863, Fax: (+86) 023 68813806, E-mail:
xzq881@163.com. |
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cerebral hemorrhage, noradrenaline, brain injury |
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AIM: To observe the changes of noradrenaline (NE) content dynamically in
the homogenate of rat brain tissues during experimental intracerebral
hemorrhage(ICH), so as to understand the role of NE in secondary brain injury.
METHODS: Seventy Wistar rats were randomly assigned into sham operation
group and ICH group, each group subdivided into different time phase points as
pre-operation, 0.5, 6, 12, 24, 48 and 72 h post-operation groups (n=5). ICH
model was established by injection of collagenase and heparin into rat caudate
nucleus, and the changes of NE content in the peripheral tissues of the
hematoma, hypothalamus and brainstem were observed respectively at following
time points as before operation and 0.5, 6, 12, 48 and 72 h after the operation.
NE was determined by high-performance liquid chromatography.
RESULTS: NE activities in the peripheral tissues of the hematoma,
hypothalamus and brainstem increased synchronously 0.5 h after operation, peaked
at 24 h, and then began to decline at 48 h. At the same time ,the
neurobehavioral score varied synchronously together with NE.
CONCLUSION: NE is involved in the pathogenesis of secondary damage of the
brain during ICH.
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