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International Journal of Biomedical Science
4(2) 125-129
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© 2005 Master Publishing Group
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Original Article
[FullText]
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Is There a Correlation between Vitamin C Status and Catecholamines Concentrations in Hemodialysis Patients? |
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Isaline Coquet1, Jean-Marc Doise1, Jean-Claude Guilland2, Catherine Vergely2, Christiane Mousson3, Luc Rochette2 |
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1 Service de Réanimation Médicale, Centre Hospitalier Universitaire, 2 boulevard Maréchal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex, France;
2 L.P.P.C.E., Facultés de Médecine et Pharmacie, 7 boulevard Jeanne d’Arc, 21033 Dijon Cedex, France;
3 Service de Néphrologie, Centre Hospitalier Universitaire, 2 boulevard Maréchal de Lattre de Tassigny, 21079 Dijon Cedex, France
Corresponding Author: Luc Rochette, Laboratoire De Physiopathologie Et Pharmacologie Cardiovasculaires Experimentales, 7 Bd Jeanne d'Arc, BP 87900, 21079 DIJON Cedex. Tel: 0380393291; Secrétariat: 0380393292; Fax: 0380393293; E-mail: luc.rochette@u-bourgogne.fr.
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ascorbyl free radical; catecholamines; haemodialysis; oxidative stress; vitamin C |
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It is well established that there is a high incidence of cardiovascular diseases in hemodialysis patients, and involvement of oxidative stress has been hypothesised in these phenomena. Plasma norepinephrine is an independent predictor of many causes of mortality in general, and high norepinephrine levels predict cardiovascular complications in end stage renal disease. The aim of our study was to evaluate the potential link between vitamin C status, a marker of oxidative stress, and catecholamine concentrations before and after hemodialysis sessions. In a prospective study of 16 chronic hemodialysis patients, ascorbyl free radical levels were directly measured using electron spin resonance spectroscopy. These values were expressed with respect to vitamin C concentrations to obtain a direct index of oxidative stress. Vitamin C, epinephrine and norepinephrine were measured by high performance liquid chromatography. The data were examined for correlations between these compounds and clinical parameters including blood pressure and heart rates. In hemodialysis patients, ascorbyl free radical/vitamin C ratios increased significantly after dialysis. No differences were observed for catecholamine concentrations during hemodialysis sessions. In multivariate analysis, the ascorbyl free radical/vitamin C ratio did not correlate with epinephrine or norepinephrine levels. In our study, plasma norepinephrine and ascorbyl free radical/vitamin C ratios were not related among patients with end-stage renal disease. From these findings, we conclude that although these two factors are likely to be involved in the same causal pathway leading to cardiovascular events, it is likely that they seem to be independent.
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